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Strain Detail

Strain information
Resource No. nbio132
Strain name VE-cadherin-Cre
Strain Nomenclature
Common name/Synonyms VE-cad-Cre mice
Strain types mutant
Background strain
Institution National Cerebral and Cardiovascular Center Research Institute
Developer Naoki Mochizuki
Depositor Naoki Mochizuki
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. Contact us
Animal Health Report
Strain description

VE-cadherin-Cre mice specifically express Cre by vascular endothelial-cadherin (Cdh5) promoter in vascular endothelial cells. This strain is used for conditional transgenic mouse system (Cre/loxP system). It's possible to produce mice expressing LacZ or GFP in the control of VE-cadherin promoter by mating between VE-cadherin-Cre mouse and LacZ reporter mouse or GFP reporter mouse carrying loxP sites. This strain is used for elucidation of role of VE-cadherin in the neovascularization of the myocardial infarction model (1). Therefore, this strain is available for the research of cardiovascular disease widely. Incidentally, cadherin is an calcium ion dependent intercellular adhesion molecule and forms cadherin familiy constructed of tissue-specific expressed molecules such as E-cadherin in the epithelium or N-cadherin in the brain. VE-cadherin specifically expresses in the vascular endothelial cell.

References
  1. Kogata N, Arai Y, Pearson JT, Hashimoto K, Hidaka K, Koyama T, Somekawa S, Nakaoka Y, Ogawa M, Adams RH, Okada M, Mochizuki N. Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization. Circ Res. 2006 Apr 14;98(7):897-904. [PMID: 16543497]
  2. Gory S, Vernet M, Laurent M, Dejana E, Dalmon J, Huber P. The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice. Blood. 1999 Jan 1;93(1):184-92. [PMID: 9864160]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Cdh5 (VE-cadherin, 7B4/cadherin-5, CD144, VE-Cad, VEC), Cre
Gene name Cadherin 5, Cre recombinase
Genotyping information Genotyping protocol for VE-cadherin-Cre mice (pdf).