HOME > mice > 11Prom-Cre mice
Strain Detail
Strain information | |||
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Resource No. | nbio128 | ||
Strain name | 11Prom-Cre | ||
Strain Nomenclature | |||
Common name/Synonyms | LP-Cre, 742-Cre | ||
Strain types | mutant | ||
Background strain | |||
Institution | Department of Bone and Cartilage Biology, Osaka University Graduate School of Medicine |
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Developer | Noriyuki Tsumaki |
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Depositor | Noriyuki Tsumaki | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
11Prom-Cre mice specifically express Cre in chondrocytes after the late stage of proliferative chondrocytes. This strain is used for conditional transgenic mouse system (Cre/loxP system). Cre regulated by Col11a2 (Type XI collagen alpha 2 chain gene) promoter. This strain is used for elucidation of in vivo roles of Smad7 about chondrocyte differentiation by specifically expressing Smad7 in chondrocytes after the late stage of proliferative chondrocytes by mating with Col11a2-LacZflox-Smad7 mouse (nbio127). This strain expects to contribute to basic research for the therapy of motor system diseases in orthopedics. |
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References |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | transgenic | ||
Gene symbol | Col11a2, Cre | ||
Gene name | Collagen, type XI, alpha 2, Cre recombinase | ||
Genotyping information |