HOME > mice > ACE2 Tg #5 mice
Strain Detail: ACE2 Tg #5 mice
| Strain information |
| Resource No. |
nbio296 |
| Strain name |
ACE2 Tg #5 |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6J Jms Slc |
| Institution |
National Institute of Infectious Diseases |
| Developer |
Kiyoshi Tanabayashi |
| Depositor |
Kiyoshi Tanabayashi |
| Conditions of distribution |
In publishing the research results obtained by use of the biological resource, the stipulation of an acknowledgment to depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
The ACE2 Tg #5 mice are transgenic mice carrying CAG-promoter-driven human angiotensin I converting enzyme 2 (hACE2), a receptor for SARS Coronavirus (SARS-CoV). The mice express hACE2 in the whole body and are highly susceptible to SARS-CoV. The strain is useful as a mouse model for SARS-CoV infection. Three lines are available (#5, #16, #17). In Japan, users of this strain need permission for recombinant DNA experiments from the Minister of Education, Culture, Sports, Science and Technology. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Tg/+ |
| Medium |
R18S3 |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
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| Live animals |
Approx. 3 months |
| Gene information |
| Mutation types |
spontaneous mutation |
| Gene symbol |
ACE2 |
| Gene name |
angiotensin I converting enzyme 2 |
| Genotyping information |
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