HOME > mice > ADAMTS13 KO mice (C57BL/6Cr congenic)
Strain Detail
Strain information | |||
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Resource No. | nbio074 | ||
Strain name | ADAMTS13 KO (C57BL/6Cr congenic) | ||
Strain Nomenclature | C57BL/6Cr-TgH(Adamts13) NCVC | ||
Common name/Synonyms | |||
Strain types | congenic | ||
Background strain | |||
Institution | National Cerebral and Cardiovascular Center Research Institute |
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Developer | Toshiyuki Miyata | ||
Depositor | Toshiyuki Miyata (Contact person: Koichi Kokame) | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
This strain is C57BL/6CrSlc congenic mouse of ADAMTS13 KO, which is Thrombotic Thrombocytopenic Purpura (TTP) model mouse and 129+Ter/SvJcl background (nbio061, ref.1). ADAMTS13 expression is different among mouse strains. That is, 129 strain expresses full length ADAMTS13 whereas C57BL/6 strain expresses C-terminal domain deleted ADAMTS13 by inserting retrotransposon into ADAMTS13 genes (2). |
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References |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | knockout | ||
Gene symbol | Adamts13 | ||
Gene name | A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13 | ||
Genotyping information |