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Strain Detail: ATF4 KO mice

Strain information
Resource No. nbio056
Strain name ATF4 KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Research Institute for Microbial Diseases, Osaka University
Developer Shizuo Akira
Depositor Shizuo Akira
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

ATF4 KO mice are knockout mice deleted for ATF4 (activating transcription factor-4), a basic-leucine zipper transcription factor to belong to ATF/CREB family.

These mice are observed serious microphthalmia because crystalline lens is degenerated by abnormaly in the developmental differentiation of lens fiber cells, though the eyes of ATF4 KO mice have normal structure of crystalline lens until 14.5 days fetal age.

Microphthalmia
normal

normal mouse

ATF4 KO mouse (microphthalmia)

ATF4 KO mouse (microphthalmia)
Reference(s)
  1. Tanaka T, Tsujimura T, Takeda K, Sugihara A, Maekawa A, Terada N, Yoshida N, and Akira S. (1998) Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells 3(12):801-10. [PMID:10096021]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Atf4 (C/ATF, CREB2, TAXREB67)
Gene name Activating transcription factor 4 (C/EBP-related ATF, cAMP-responsive element-binding protein 2, tax-responsive enhancer element B67)
Genotyping information