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Strain Detail: B10A.Bcgr

Strain information
Resource No. nbio267
Strain name B10A.Bcgr
Strain Nomenclature
Common name/Synonyms
Strain types congenic
Background strain C57BL/10.A
Institution Department of Biology, University of California
Developer D. Radzioch
Depositor Fumiko Mizuno (Nara Medical University)
Conditions of distribution without conditions : contact us
Animal Health Report
Strain description

The B10A.Bcgr mice are congenic mice carrying resistant type (Bcgr) of Nramp1 (Slc11a1) gene with C57BL/10.A genetic background. The product of the Nramp1 gene, a membrane protein of macrophages, determines a sensitivity to Mycobacterium bovis (Bacille de Calmette et Guérin, BCG), Salmonella typhimurium, and Leishmania donovani. The B10A.Bcgr mice are resistant to pathogens shown above.

References
  1. Nesbitt MN, Skamene E. Recombinant inbred mouse strains derived from A/J and C57BL/6J: a tool for the study of genetic mechanisms in host resistance to infection and malignancy. J Leukoc Biol. 1984, 36(3):357-64.
  2. Radzioch D, Hudson T, Boulé M, Barrera L, Urbance JW, Varesio L, Skamene E. Genetic resistance/susceptibility to mycobacteria: phenotypic expression in bone marrow derived macrophage lines. J Leukoc Biol. 1991, 50(3):263-72.
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals Live animals only (Please contasct us.)
Gene information
Mutation types spontaneous mutation
Gene symbol Slc11a1
Gene name solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Genotyping information