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Strain Detail: B6.ICGN-C1raC1s1C1rb mice

Strain information
Resource No. nbio323
Strain name B6.ICGN-C1raC1s1C1rb
Strain Nomenclature
Common name/Synonyms
Strain types congenic
Background strain C57BL/6J Jcl
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Kozue Uchio-Yamada
Depositor Kozue Uchio-Yamada
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Mice of the strain have mutations in C1 (a component of classical complement pathway) alleles, i.e., complete deletion of C1s1 and partial deletions of C1ra and C1rb (see figure below). The mice express C1ra-C1rb fusion proteins in the liver, but C1r proteins are undetectable in their peripheral blood. The mice can be used as C1r/C1s deficient mice with C57BL/6J background.

structure of C1 allele
Reference(s)
  1. Uchio-Yamada K, Tanaka M, and Manabe N. (2019) C1r/C1s deficiency is insufficient to induce murine systemic lupus erythematosus. Genes Immun 20(2):121-130. [PMID:29550838]
  2. Tamura K, Uchio-Yamada K, Manabe N, Noto T, Hirota R, Unami A, Matsumoto M, and Miyamae Y. (2013) Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice. Nephron Exp. Nephrol. 123(3-4):34-45. [PMID:23989031]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals Live animals only (Please contasct us.)
Gene information
Mutation types congenic
Gene symbol C1ra, C1s1, C1rb
Gene name Complement component 1, r subcomponent A; Complement component 1, s subcomponent 1; Complement component 1, r subcomponent B
Genotyping information