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Strain Detail

Strain information
Resource No. nbio196
Strain name B6-SR-PSOX
Strain Nomenclature
Common name/Synonyms B6-CXCL16
Strain types mutant
Background strain C57BL/6
Institution Graduate School of Biostudies, Kyoto University
Developer
Depositor Shin Yonahara
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

B6-SR-PSOX mice are knockout mice of SR-PSOX/CXCL16 and C57BL/6 gene background. We also supply of BALB-CXCL16 mice (nbio197), which are BALB/c gene background. SR-PSOX, a molecule cloned as scavenger receptor, is identified as transmembrane chemokine CXCL16 involved in migration of NKT cell or activated T-cell. This strain decreases the number of NKT cells in liver due to inhibit NKT cells homing to liver, whereas this strain suppresses the onset of ConA-induced hepatitis. The research of this strain showed that SR-PSOX expressed in antigen-presenting cells was essential for promoting IFN-γ production in NKT cells and inducing Th1-type immune response. It considers that Th1-type immune response may be regulated by the control of SR-PSOX/CXCL16 activity in the infection of bacteria or viruses.

References
  1. Shimaoka T, Seino K, Kume N, Minami M, Nishime C, Suematsu M, Kita T, Taniguchi M, Matsushima K, Yonehara S. Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. J Immunol. 2007 Dec 15;179(12):8172-9.
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Cxcl16
Gene name chemokine (C-X-C motif) ligand 16
Genotyping information