HOME > mice > BALB-SR-PSOX mice
Strain Detail
Strain information | |||
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Resource No. | nbio197 | ||
Strain name | BALB-SR-PSOX | ||
Strain Nomenclature | |||
Common name/Synonyms | BALB-CXCL16 | ||
Strain types | mutant | ||
Background strain | BALB/c | ||
Institution | Graduate School of Biostudies, Kyoto University | ||
Developer | |
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Depositor | Shin Yonahara | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
BALB-SR-PSOX mice are knockout mice of SR-PSOX/CXCL16 and BALB/c gene background. We also supply of B6-CXCL16 mice (nbio196), which are C57BL/6 gene background. SR-PSOX, a molecule cloned as scavenger receptor, is identified as transmembrane chemokine CXCL16 involved in migration of NKT cell or activated T-cell. This strain decreases the number of NKT cells in liver due to inhibit NKT cells homing to liver, whereas this strain suppresses the onset of ConA-induced hepatitis. The research of this strain showed that SR-PSOX expressed in antigen-presenting cells was essential for promoting IFN-γ production in NKT cells and inducing Th1-type immune response. It considers that Th1-type immune response may be regulated by the control of SR-PSOX/CXCL16 activity in the infection of bacteria or viruses. |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | |||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | |||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | knockout | ||
Gene symbol | Cxcl16 | ||
Gene name | chemokine (C-X-C motif) ligand 16 | ||
Genotyping information |