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Strain Detail: C57BL/6J-Pros1 KO NCVC

Strain information
Resource No. nbio290
Strain name C57BL/6J-Pros1 KO NCVC
Strain Nomenclature
Common name/Synonyms PS-KO(B6)
Strain types mutant
Background strain C57BL/6J Jms Slc
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

The PS-KO(B6) mice are Pros1-deficient C57BL/6 mice. The Pros1 gene encodes a blood coagulation control factor, protein S. Homozygous (total) deficiency in protein S is embryonic lethal, whereas mice with heterozygous deficiency reproduce normally. The strain is useful as a mouse model for protein S deficiency, one of the primary causes for congenital embolism.

References
  1. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, Miyata T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015, 126(19):2247-53.
Resource information
Cryopreserved sperm In-house Genotype heterozygous
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype Mix of heterozygous and wild-type
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Pros1
Gene name protein S (α)
Genotyping information