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Strain Detail: C57BL/6J-Pros1 K196E NCVC

Strain information
Resource No. nbio279
Strain name C57BL/6J-Pros1 K196E NCVC
Strain Nomenclature
Common name/Synonyms PS-K196E knockin(B6)
Strain types congenic
Background strain C57BL/6J Jms Slc
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

The PS-K196E knockin (B6) mice are knock-in mice carrying c.586A>G (p.K196E) mutation introduced in Pros1 locus of C57BL/6 mice by knock-in technology. Pros1 gene encodes a blood coagulation control factor, protein S. The c.586A>G (p. K196E) mutation, found in approximately 2% of the Japanese population, is a hereditary risk for venous thromboembolism. A study using this strain (Ref. 1) indicated that this mutation can be an exacerbation factor for venous thromboembolisms, such as pulmonary embolism. The strain is useful as a mouse model for research on Japanese-type embolism.

References
  1. Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, Miyata T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015, 126(19):2247-53.
Resource information
Cryopreserved sperm In-house Genotype Pros1 E/E homozygous
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live mouse
Gene information
Mutation types knockin
Gene symbol Pros1
Gene name protein S (α)
Genotyping information