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Strain Detail: Cataract/Nakano mice

Strain information
Resource No. nbio252
Strain name Cataract/Nakano
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain Unknown
Institution Laboratory Animal Science, Kitasato University School of Medicine (National Institute of Health)
Developer Kenji Nakano
Depositor Seniti Furudate
Conditions of distribution

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Animal Health Report
Strain description

The Cataract/Nakano mice are spontaneous mutants with hereditary cataract. The mice were derived from mice that Dr. Kenji Nakano discovered as spontaneous mutants with eye abnormalities in an inbred strain of mice with wa-1 and belt genes kept at the National Institute of Health in Tokyo (Ref. 1). The mode of inheritance is autosomal recessive. This hereditary cataract is caused by a hypomorphic mutation in the coproporphyrinogen oxidase (Cpox) gene (Ref. 2).

photo of Cataract/Nakano mouse
References
  1. Nakano K, Yamamoto S, Kutsukake G, Ogawa H, Nakajima A, Takano E. Hereditary cataract in mice. Jpn J Clin Ophthalmol 14(11):1772-1776, 1960. [In Japanese]
  2. Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K. Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res. 2013 Jul;112:45-50.
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype nct/nct
Method Slow-Freezing method (Minesuke Yokoyama's method)
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo Within 1 month
Live mouse Approx. 2 months
Gene information
Mutation types spontaneous mutation
Gene symbol Cpox
Gene name coproporphyrinogen oxidase
Genotyping information