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Strain Detail: CIRP-KO mice

Strain information
Resource No. nbio207
Strain name CIRP-KO
Strain Nomenclature C57BL/6-Cirbptm1cmbKyo
Common name/Synonyms
Strain types mutant
Background strain
Institution Educational Development Center, Kyoto University of Advanced Science
Developer
Depositor Katsuhiko Itoh
Conditions of distribution

Users of this strain should cite the article designated by the depositor (Ref. 1) upon publication of the research results. contact us
Animal Health Report
Strain description

CIRP-KO mice are knockout mice of Cold inducible RNA binding protein (Cirbp, also called CIRP). Although the number of undifferentiated spermatogonia is reduced in males of the strain, the males are not sterile.
Reference(s)
  1. Masuda T, Itoh K, Higashitsuji H, Higashitsuji H, Nakazawa N, Sakurai T, Liu Y, Tokuchi H, Fujita T, Zhao Y, Nishiyama H, Tanaka T, Fukumoto M, Ikawa M, Okabe M, and Fujita J. (2012) Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Proc Natl Acad Sci U S A 109(27):10885-90. [PMID:22711815]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Cirbp
Gene name cold inducible RNA binding protein
Genotyping information