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Strain Detail: Cmah Tg VH-H mice

Strain information
Resource No. nbio065
Strain name Cmah Tg VH-H
Strain Nomenclature
Common name/Synonyms Lymphocyte-specific Cmah transgenic mouse line H
Strain types mutant
Background strain
Institution Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University
Developer Hiromu Takematsu
Depositor Hiromu Takematsu
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Cmah Tg VH-H mice specifically express Cmah (CMP-Neu5Ac hydroxylase), an enzyme which converts molecular species from N-Acetylneuraminic acid to N‐glycolylneuraminic acid, in lymphocytes. These mice express high Cmah mainly in B-cells, thus it supplements loss of Cmah from somatic cell copies down-regulated in the B-cell activation. As a result, Cmah Tg mice keep to express Cmah in activated B-cells. This strain is available for disease research about immunosuppression. The line H shows specifically middle expression of Cmah in B-cells. We supply other 2 lines, G line (nbio064) and JA line (nbio066).
Reference(s)
  1. Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H. (2014) Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells. J. Biol. Chem. 289(3):1564-79. [PMID:24297165]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Cmah
Gene name CMP-Neu5Ac hydroxylase
Genotyping information