HOME > mice > Cmah Tg VH-JA mice
Strain Detail
Strain information | |||
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Resource No. | nbio066 | ||
Strain name | Cmah Tg VH-JA | ||
Strain Nomenclature | |||
Common name/Synonyms | Lymphocyte-specific Cmah transgenic mouse line JA |
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Strain types | mutant | ||
Background strain | |||
Institution | Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University | ||
Developer | Hiromu Takematsu |
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Depositor | Hiromu Takematsu | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
Cmah Tg VH-JA mice specifically express Cmah (CMP-Neu5Ac hydroxylase), an enzyme which converts molecular species from N-Acetylneuraminic acid to N‐glycolylneuraminic acid, in lymphocytes. These mice express high Cmah mainly in B-cells, thus it supplements loss of Cmah from somatic cell copies down-regulated in the B-cell activation. As a result, Cmah Tg mice keep to express Cmah in activated B-cells. This strain is available for disease research about immunosuppression. The line JA shows middle expression of Cmah. We supply other 2 lines, G line (nbio064) and H line (nbio065). |
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References | |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | transgenic | ||
Gene symbol | Cmah | ||
Gene name | CMP-Neu5Ac hydroxylase | ||
Genotyping information |