HOME > mice > Cmah Tg VH-JA mice
Strain Detail
| Strain information | |||
|---|---|---|---|
| Resource No. | nbio066 | ||
| Strain name | Cmah Tg VH-JA | ||
| Strain Nomenclature | |||
| Common name/Synonyms | Lymphocyte-specific Cmah transgenic mouse line JA |
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| Strain types | mutant | ||
| Background strain | |||
| Institution | Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University | ||
| Developer | Hiromu Takematsu |
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| Depositor | Hiromu Takematsu | ||
| Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
| Animal Health Report | |||
| Strain description |
Cmah Tg VH-JA mice specifically express Cmah (CMP-Neu5Ac hydroxylase), an enzyme which converts molecular species from N-Acetylneuraminic acid to N‐glycolylneuraminic acid, in lymphocytes. These mice express high Cmah mainly in B-cells, thus it supplements loss of Cmah from somatic cell copies down-regulated in the B-cell activation. As a result, Cmah Tg mice keep to express Cmah in activated B-cells. This strain is available for disease research about immunosuppression. The line JA shows middle expression of Cmah. We supply other 2 lines, G line (nbio064) and H line (nbio065). |
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| References | |
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| Resource information | |||
| Cryopreserved sperm | In-house | Genotype | |
| Medium | FERTIUP | ||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | |||
| Medium | EFS40 | ||
| From other institutions | Mating System | ||
| Genotype | |||
| Medium | |||
| Strain status / Availability | Cryopreserved sperm | Within 1 month | |
| Cryopreserved embryo | Within 1 month | ||
| Live mouse |
Approx. 2 months | ||
| Gene information | |||
| Mutation types | transgenic | ||
| Gene symbol | Cmah | ||
| Gene name | CMP-Neu5Ac hydroxylase | ||
| Genotyping information | |||