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Strain Detail: Conditional KI (Bim) mice

Strain information
Resource No. nbio346
Strain name Conditional KI (Bim)
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J
Institution (1) Department of Pharmacology, National Research Institute for Child Health and Development, and (2) UNITECH Co., Ltd.
Developer Junji Yamauchi (1) and Hisashi Tomaru (2)
Depositor Junji Yamauchi (1) and Hisashi Tomaru (2)
Conditions of distribution Limited to collaborative research with depositors. Users shall cite references specified by the depositor when publishing research results. Users shall give an acknowledgment to the depositor when publishing the research results. Users shall obtain the consent of the depositor in advance. contact us
Animal Health Report
Strain description

Bim, a.k.a. Bcl2l11 (BCL2-like 11 (apoptosis facilitator)), is one of BCL-2 family members and acts as an anti- or pro-apoptotic regulator. The strain is a conditional knockin mouse strain in which Bim expresses in tissues with Cre expression. The integrated transgene has a stop cassette surrounded by loxP between the CAG promoter and the Bim cDNA. The stop cassette is removed in the tissues where Cre is expressed, and the Bim becomes expressed. The strain is useful for BIM research.
Reference(s)
Resource information
Cryopreserved sperm In-house Genotype heterozygous
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype heterozygous / wild-type
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types Conditional KI
Gene symbol Bim (a.k.a., Bcl2l11, 1500006F24Rik, Bod)
Gene name BCL2-like 11 (apoptosis facilitator)
Genotyping information