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Strain Detail

Strain information
Resource No. nbio247
Strain name Cytohesin-1 KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Pharmacology and Laboratory Animal Resource Facility, National Research Institute for Child Health and Development
Developer Junji Yamauchi, Tomohiro Torii
Depositor Junji Yamauchi, Tomohiro Torii
Conditions of distribution In publishing the research results obtained by use of the animal resource, a citation of the following literature (ref.1) and the stipulation of an acknowledgment to depositor designated by the depositor is requested.
It's necessary to obtain depositor's consent on use of biological resources.
Only for collaboration with the depositor : contact us
Animal Health Report
Strain description

This strain is a systemic knockout mouse expressing cytohesin-1. This straiin has no effect on reproduction and survival. Cytohesin-1 is a guanine nucleotide exchange factor (GEF) and mostly expressing in immune cells. These mice are delayed the myelination in developmental process, consequently reduced the yield of myelin. This strain is expected to apply for the research of peripheral neurodegenerative disease such as hypomyelination.

References
  1. Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. Sci Signal. 2012 Sep 25;5(243):ra69.
  2. Goda N, Tanoue A, Kikuchi S, Tsujimoto G. Cloning and characterization of the promoter of murine cytohesin-1 gene. Biochim Biophys Acta. 2000 Sep 7;1493(1-2):195-9.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Cyth1
Gene name cytohesin 1
Genotyping information