HOME > mice > Cytohesin-1 KO mice
Strain Detail: Cytohesin-1 KO mice
| Strain information |
| Resource No. |
nbio247 |
| Strain name |
Cytohesin-1 KO |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
|
| Institution |
Department of Pharmacology and Laboratory Animal Resource Facility, National Research Institute for Child Health and Development |
| Developer |
Junji Yamauchi, Tomohiro Torii |
| Depositor |
Junji Yamauchi, Tomohiro Torii |
| Conditions of distribution |
In publishing the research results obtained by use of the animal resource, a citation of the following literature (ref.1) and the stipulation of an acknowledgment to depositor designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor. contact us |
| Animal Health Report |
|
| Strain description |
This strain is a systemic knockout mouse expressing cytohesin-1. This straiin has no effect on reproduction and survival. Cytohesin-1 is a guanine nucleotide exchange factor (GEF) and mostly expressing in immune cells. These mice are delayed the myelination in developmental process, consequently reduced the yield of myelin. This strain is expected to apply for the research of peripheral neurodegenerative disease such as hypomyelination. |
| Reference(s) |
- Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, and Tanoue A. (2012) Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development. Sci Signal 5(243):ra69. [PMID:23012656]
- Goda N, Tanoue A, Kikuchi S, and Tsujimoto G. (2000) Cloning and characterization of the promoter of murine cytohesin-1 gene. Biochim Biophys Acta 1493(1-2):195-9. [PMID:10978522]
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
FERTIUP |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Cyth1 |
| Gene name |
cytohesin 1 |
| Genotyping information |
|
