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Strain Detail

Strain information
Resource No. nbio231
Strain name Delta NHE1-TG
Strain Nomenclature
Common name/Synonyms ΔNHE1-TG
Strain types mutant
Background strain
Institution Department of Molecular Physiology, National Cardiovascular Center Research Institute
Developer Shigeo Wakabayashi
Depositor Shigeo Wakabayashi
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources.
Only for collaboration with the depositor : contact us
Animal Health Report
Strain description

This strain is specifically overexpressing activated NHE1 in myocardia, therefore it's a cardiac hypertrophy and heart failure model triggered by increase of intracellular Na+ concentration by NHE1 activation. NHE1 is a important ion transporter to keep cell homeostasis and a member of Na+/H+ Exchangers (NHE) family.

References
  1. Nakamura TY, Iwata Y, Arai Y, Komamura K, Wakabayashi S. Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Circ Res. 2008 Oct 10;103(8):891-9.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol SLC9A1
Gene name solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member
Genotyping information