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Strain Detail: Dglucy cKO mice
| Strain information |
| Resource No. |
nbio364 |
| Strain name |
Dglucy cKO |
| Strain Nomenclature |
RIKEN cDNA 9030617O03 conditional KO (-/-) Cre(-) |
| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
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| Institution |
Department of Cardiovascular Medicine, Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine |
| Developer |
Satoaki Matoba |
| Depositor |
Satoaki Matoba |
| Conditions of distribution |
without conditions: contact us |
| Animal Health Report |
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| Strain description |
D-glutamate cyclase (Dglucy, a.k.a.,9030617O03Rik) is an enzyme which converts D-glutamate to 5-oxo-D-proline. The Dglucy cKO mice can be used for production of conditional KO mice of the Dglucy gene since the mice are heterozygous for a floxed Dglucy gene (Dglucy-flox/+). The mice are useful for analyzing D-amino acid functions in mammals. Dglucy KO mice are also available. |
| Reference(s) |
- Ariyoshi M, Katane M, Hamase K, Miyoshi Y, Nakane M, Hoshino A, Okawa Y, Mita Y, Kaimoto S, Uchihashi M, Fukai K, Ono K, Tateishi S, Hato D, Yamanaka R, Honda S, Fushimura Y, Iwai-Kanai E, Ishihara N, Mita M, Homma H, and Matoba S. (2017) D-Glutamate is metabolized in the heart mitochondria. Sci Rep 7: 43911. [PMID:28266638]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
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| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
conditional KO |
| Gene symbol |
Dglucy, a.k.a., 9030617O03Rik |
| Gene name |
D-glutamate cyclase |
| Genotyping information |
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