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Strain Detail: Dglucy cKO mice

Strain information
Resource No. nbio364
Strain name Dglucy cKO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Cardiovascular Medicine, Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
Developer Satoaki Matoba
Depositor Satoaki Matoba
Conditions of distribution

Users shall give an acknowledgment to the depositor when publishing the research results.

Animal Health Report
Strain description

D-glutamate cyclase (Dglucy, a.k.a.,9030617O03Rik) is an enzyme which converts D-glutamate to 5-oxo-D-proline. The Dglucy cKO mice can be used for production of conditional KO mice of the Dglucy gene since the mice are heterozygous for a floxed Dglucy gene (Dglucy-flox/+). The mice are useful for analyzing D-amino acid functions in mammals. Dglucy KO mice are also available.

Reference(s)
  1. Ariyoshi M, Katane M, Hamase K, Miyoshi Y, Nakane M, Hoshino A, Okawa Y, Mita Y, Kaimoto S, Uchihashi M, Fukai K, Ono K, Tateishi S, Hato D, Yamanaka R, Honda S, Fushimura Y, Iwai-Kanai E, Ishihara N, Mita M, Homma H, and Matoba S. (2017) D-Glutamate is metabolized in the heart mitochondria. Sci Rep 7: 43911. [PMID:28266638]
Resource information
Cryopreserved sperm In-house Genotype Heterozygous
Medium Fertiup
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live animals Approx. 2 months
Gene information
Mutation types conditional KO
Gene symbol Dglucy, a.k.a., 9030617O03Rik
Gene name D-glutamate cyclase
Genotyping information