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Strain Detail: Dglucy-KO mice

Strain information
Resource No. nbio365
Strain name Dglucy-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Cardiovascular Medicine, Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
Developer Satoaki Matoba
Depositor Satoaki Matoba
Conditions of distribution

Users shall give an acknowledgment to the depositor when publishing the research results.

Animal Health Report
Strain description

D-glutamate cyclase (Dglucy, a.k.a.,9030617O03Rik) is an enzyme which converts D-glutamate to 5-oxo-D-proline. The Dglucy-KO mice are knockout mice for the Dglucy gene. The mice are useful for analyzing D-amino acid functions in mammals. Mice for conditional Dglucy KO mouse production (Dglucy cKO mice) are also available.

Reference(s)
  1. Ariyoshi M, Katane M, Hamase K, Miyoshi Y, Nakane M, Hoshino A, Okawa Y, Mita Y, Kaimoto S, Uchihashi M, Fukai K, Ono K, Tateishi S, Hato D, Yamanaka R, Honda S, Fushimura Y, Iwai-Kanai E, Ishihara N, Mita M, Homma H, and Matoba S. (2017) D-Glutamate is metabolized in the heart mitochondria. Sci Rep 7: 43911. [PMID:28266638]
Resource information
Cryopreserved sperm In-house Genotype Heterozygous
Medium Fertiup
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype Mix of heterozygotes and wild-types
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Dglucy, a.k.a., 9030617O03Rik
Gene name D-glutamate cyclase
Genotyping information