HOME > mice > Col11a2-lacZ-dnTgfbr2-#2 mice
Strain Detail
Strain information | |||
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Resource No. | nbio173 | ||
Strain name | Col11a2-lacZ-dnTgfbr2-#2 | ||
Strain Nomenclature | |||
Common name/Synonyms | DTR#10 | ||
Strain types | mutant | ||
Background strain | |||
Institution | Department of Bone and Cartilage Biology, Osaka University Graduate School of Medicine |
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Developer | Noriyuki Tsumaki |
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Depositor | Noriyuki Tsumaki | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
Col11a2-lacZ-dnTgfbr2-#2 mice are loxP mice to construct cartilaginous conditional transgenic mouse system and regulated transgene expression by Col11a2 (Type XI collagen alpha 2 chain gene) promoter/intron 1 enhancer. The double transgenic mouse produced by mating between Col11a2-lacZ-dnTgfbr2-#2 mouse and Prx1-Cre mouse specifically expresses dominant-negative TGFbeta receptor type II in the cartilage. This strain expects to contribute to basic research for the therapy of motor system diseases in orthopedics, such as dyschondroplasia. |
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References |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | conditional transgenic | ||
Gene symbol | Tgfbr2 | ||
Gene name | Transforming growth factor, beta receptor II | ||
Genotyping information |