HOME > mice > Col11a2-lacZ-dnTgfbr2-#2 mice
Strain Detail: Col11a2-lacZ-dnTgfbr2-#2 mice
| Strain information |
| Resource No. |
nbio173 |
| Strain name |
Col11a2-lacZ-dnTgfbr2-#2 |
| Strain Nomenclature |
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| Common name/Synonyms |
DTR#10 |
| Strain types |
mutant |
| Background strain |
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| Institution |
Department ofBoneand Cartilage Biology, Osaka University Graduate School of Medicine |
| Developer |
Noriyuki Tsumaki |
| Depositor |
Noriyuki Tsumaki |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Col11a2-lacZ-dnTgfbr2-#2 mice are loxP mice to construct cartilaginous conditional transgenic mouse system and regulated transgene expression by Col11a2 (Type XI collagen alpha 2 chain gene) promoter/intron 1 enhancer. The double transgenic mouse produced by mating between Col11a2-lacZ-dnTgfbr2-#2 mouse and Prx1-Cre mouse specifically expresses dominant-negative TGFβ receptor type II in the cartilage. This strain expects to contribute to basic research for the therapy of motor system diseases in orthopedics, such as dyschondroplasia. |
| Reference(s) |
- Hiramatsu K, Iwai T, Yoshikawa H, and Tsumaki N. (2011) Expression of dominant negative TGF-β receptors inhibits cartilage formation in conditional transgenic mice. J Bone Miner Metab 29(4):493-500. [PMID:21213115]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
conditional transgenic |
| Gene symbol |
Tgfbr2 |
| Gene name |
Transforming growth factor, beta receptor II |
| Genotyping information |
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