Strain Detail: EdnrA-LacZ mice

It's getting known that endothelin receptor type A (Ednra) which is one of the endothelin receptor known as endothelium-derived vasoconstrictive peptide plays an important role of the development of tissues derived from neural crest in the embryogenesis. Ednra knockout mice are observed the anomaly of mandible development in the stage of maxillofacial development and cardiac formation in the stage of cardiovascular development, and Ednra homozygous knockout mice die immediately after birth. This strain introduced LacZ into Ednra allele is able to visualize Ednra-expressing cells and useful for the observation of Ednra-expressing cells in the fetal stage. This strain is C57BL/6Cr Slc gene background. It's possible to supply EdnrA-EGFP mice introduced EGFP in the same method.

1. Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, Heude E, Ekker M, Levi G, and Kurihara H. (2008) An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A 105(48):18806-11. [PMID:19017795]
2. Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff-Swiercz DA, Offermanns S, Kurihara Y, and Kurihara H. (2008) Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development 135(4):755-65. [PMID:18199583]
3. Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, and Kurihara H. (2010) Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development 137(22):3823-33. [PMID:20929948]