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Strain Detail: Eif2b5-KO mice
| Strain information |
| Resource No. |
nbio420 |
| Strain name |
Eif2b5-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Mice in which Eif2b5, one of the causative genes of progressive leukoencephalopathy, was knocked out by genome editing.
This strain was created by setting gRNA at two locations in the Eif2b5 gene and deleting Exons 3 to 7.
This strain may be useful as a model of progressive leukoencephalopathy. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
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| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Eif2b5 |
| Gene name |
eukaryotic translation initiation factor 2B, subunit 5 epsilon |
| Genotyping information |
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