| Resource No. |
nbio002 |
| Strain name |
EL |
| Strain Nomenclature |
|
| Common name/Synonyms |
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| Strain types |
inbred |
| Background strain |
|
| Institution |
National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Health) |
| Developer |
Kiyoshi Imaizumi |
| Depositor |
|
| Conditions of distribution |
without conditions: contact us |
| Animal Health Report |
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| Strain description |
The EL strain is albino mice found in the process of researching spontaneous brain edema mice by Imaizumiet al. at the National Institute of Health in 1954 (Ref. 1). Epileptic seizures are easily induced in EL mice by stimuli on the postural change such as tossed-up movement. EL mice are considered as models for human complex partial seizures following secondarily generalized seizures (temporal lobe epilepsy) by study of the electroencephalogram. The strain name was formerly written "El", but presently it's recommended to write "EL" according to rules for nomenclature of mouse strains. Especially, the young males must be carefully bred because they often develop urinary retention. The strain is effectively bred using the slanted cage we invented. We also show that the low protein diet (CE-7, CLEA Japan) is good for reproduction efficiency. |
| Reference(s) |
- Imaizumi K, Ito S, Kutukake G, Takizawa T, Fujiwara K, Tutikawa K (1959). Epilepsy Like Anomaly of Mice. Experimental Animals 8(1):6-10.
- Imaizumi K, Nakano T (1964). Mutant stocks, strain El. Mouse News Letter 31:57.
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