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Strain Detail: FIR(Flox/+) mice

Strain information
Resource No. nbio195
Strain name FIR(Flox/+)
Strain Nomenclature
Common name/Synonyms FIR (Flox/+) hetero knockout mouse
Strain types mutant
Background strain
Institution Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University
Developer Kazuyuki Matsushita
Depositor Kazuyuki Matsushita
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. But it isn'tindispensable condition.:contact us
Animal Health Report
Strain description

FIR(Flox/+)mice are conditional knockout mice of FUSE-binding protein-interacting repressor (FIR) gene, a c-myc gene transcriptional repressor. Targeting allele is integraded two loxP sites derived from bacteriophage P1 flanking exon 3, 4 of FIR gene and neomycin resistance gene derived from E. coli. This strain is expected to apply for the elucidation of a role of FIR in oncogenesis of various organs.

  1. Matsushita K, Tomonaga T, Shimada H, Shioya A, Higashi M, Matsubara H, Harigaya K, Nomura F, Libutti D, Levens D, and Ochiai T. (2006) An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis. Cancer Res 66(3):1409-17. [PMID:16452196]
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types conditional KO
Gene symbol FIR
Gene name FUSE-binding protein-interacting repressor
Genotyping information