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Strain Detail: FOXO1 Tg mice
|Strain name||FOXO1 Tg|
|Institution||Division of basic nutrition, National Institute of Health and Nutrition|
|Conditions of distribution||It's necessary to obtain depositor's consent on use of biological resources. contact us|
|Animal Health Report|
FOXO1 mice are transgenic mice specifically overexpressing FOXO1 in skeletal muscle. this strain is available for elucidating molecular mechanism of muscle atrophy and development of preventive medicine. Muscle atrophy is caused by being confined to bed, putting a broken leg or arm in a cast and so on. As a result, skeletal muscle mass and function decrease gradually. However, the detailed molecular mechanisms on this process are not clearly understood.
FOXO1 is a forkhead transcription factor and nuclear hormone receptor cofactor. Gene expression of FOXO1 is increased remarkably in mouse skeletal muscle during muscle atrophy by energy deficiency such as fasting. It shows that FOXO1 decreases skeletal muscle mass and down-regulatesred muscle fiber geneby using FOXO1 mice.
|From other institutions||Genotype|
|Cryopreserved embryo||In-house||Mating System|
|From other institutions||Mating System|
|Strain status / Availability||Cryopreserved sperm||Within 1 month|
|Cryopreserved embryo||Within 1 month|
|Live animals||Approx. 2 months|
|Gene name||Forkhead box O1|
|Genotyping information||Genotyping protocol for FOXO1 Tg mice (pdf).|