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Strain Detail

Strain information
Resource No. nbio023
Strain name FOXO1 Tg
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer Yasutomi Kamei
Depositor Yasutomi Kamei
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

FOXO1 mice are transgenic mice specifically overexpressing FOXO1 in skeletal muscle. this strain is available for elucidating molecular mechanism of muscle atrophy and development of preventive medicine. Muscle atrophy is caused by being confined to bed, putting a broken leg or arm in a cast and so on. As a result, skeletal muscle mass and function decrease gradually. However, the detailed molecular mechanisms on this process are not clearly understood.

FOXO1 is a forkhead transcription factor and nuclear hormone receptor cofactor. Gene expression of FOXO1 is increased remarkably in mouse skeletal muscle during muscle atrophy by energy deficiency such as fasting. It shows that FOXO1 decreases skeletal muscle mass and down-regulates red muscle fiber gene by using FOXO1 mice.

References
  1. Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem. 2004 Sep 24;279(39):41114-23.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Foxo1
Gene name Forkhead box O1
Genotyping information Genotyping protocol for FOXO1 Tg mice (pdf).