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Strain Detail: Glb1E6-KO mice

Strain information
Resource No. nbio417
Strain name Glb1E6-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description Glb1-WB

Our laboratory has used knockout (KO) mice (BKO) of the Glb1 gene as a mouse model for GM1 gangliosidosis. However, BKO mice have some drawbacks, such as the expression of an unwanted gene (Neo resistance gene), so we generated new KO mice by deleting exon 6 in the B6N background by genome editing. The loss of the GLB1 protein was confirmed (see WB Fig.) and, this strain is expected to be used as a mouse model for GM1 gangliosidosis like BKO.

Resource information
Cryopreserved sperm In-house Genotype Heterozygous
Medium Fertiup
From other institutions Genotype
Cryopreserved embryo In-house Mating System Heterozyous x B6NCr Slc
Genotype Heterozygous or wild
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Glb1
Gene name galactosidase, beta 1
Genotyping information