HOME > mice > Hps4-KO mice
Strain Detail: Hps4-KO mice
| Strain information |
| Resource No. |
nbio357 |
| Strain name |
Hps4-KO |
| Strain Nomenclature |
|
| Common name/Synonyms |
|
| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
 A mouse strain in which Hps4, one of the genes responsible for Hermansky-Pudlak syndrome (HPS), is knocked out by genome editing (CRISPR/Cas9). Guide RNAs were set at two locations (Exons 3 and 14) in the Hps4 gene, and most of the coding sequence was deleted by genome editing. Homozygous KO mice have a paler coat color than C57BL/6N wild-type mice (B6 mice, see photos). The strain is expected to be used as an HPS model. |
| Reference(s) |
|
| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
|
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
|
| Genotype |
|
| Medium |
|
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Hps4 |
| Gene name |
HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 |
| Genotyping information |
|
