HOME > mice > Tg-Alpha-beta Crystallin(Arg120Gly) mice

Strain Detail

Strain information
Resource No. nbio230
Strain name Tg-Alpha-beta Crystallin(Arg120Gly)
Strain Nomenclature
Common name/Synonyms HSPB5 R120G Tg
Strain types mutant
Background strain
Institution Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University
Developer Atsushi Sanbe
Depositor Atsushi Sanbe
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources.: contact us
Animal Health Report
Strain description

This strain is desmin-related cardiomyopathy model mice and cardiomyocyte-specifically expressing CryAB (R120G) which is a point mutant of CryAB (also called HSPB), which is one of the low-molecular-weight stress proteins (ref.1). It shows that these mice are palliated symptoms of desmin-related cardiomyopathy and prolonged survival by antianginal drug nicorandil which is a ATP-sensitive potassium channel opener (ref.2).

References
  1. Wang X, Osinska H, Klevitsky R, Gerdes AM, Nieman M, Lorenz J, Hewett T, Robbins J. Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice. Circ Res. 2001 Jul 6;89(1):84-91.
  2. Sanbe A, Marunouchi T, Yamauchi J, Tanonaka K, Nishigori H, Tanoue A. Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice. PLoS One. 2011 Apr 25;6(4):e18922.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Cryab
Gene name crystallin, alpha B
Genotyping information