HOME > mice > Tg-Alpha-beta Crystallin(Arg120Gly) mice
Strain Detail
Strain information | |||
---|---|---|---|
Resource No. | nbio230 | ||
Strain name | Tg-Alpha-beta Crystallin(Arg120Gly) | ||
Strain Nomenclature | |||
Common name/Synonyms | HSPB5 R120G Tg | ||
Strain types | mutant | ||
Background strain | |||
Institution | Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University | ||
Developer | Atsushi Sanbe | ||
Depositor | Atsushi Sanbe | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources.: contact us | ||
Animal Health Report | |||
Strain description |
This strain is desmin-related cardiomyopathy model mice and cardiomyocyte-specifically expressing CryAB (R120G) which is a point mutant of CryAB (also called HSPB), which is one of the low-molecular-weight stress proteins (ref.1). It shows that these mice are palliated symptoms of desmin-related cardiomyopathy and prolonged survival by antianginal drug nicorandil which is a ATP-sensitive potassium channel opener (ref.2). |
||
References |
|
||
Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | transgenic | ||
Gene symbol | Cryab | ||
Gene name | crystallin, alpha B | ||
Genotyping information |