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Strain Detail

Strain information
Resource No. nbio004
Strain name ICGN
Strain Nomenclature
Common name/Synonyms ICR-derived glomerulonephritis mice
Strain types inbred
Background strain
Institution National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Health)
Developer Atsuo Ogura
Depositor
Conditions of distribution without conditions : contact us
Animal Health Report
Strain description Photo of ICGN mice

ICR-derived glomerulonephritis (ICGN) mice, a novel inbred strain of mice with a hereditary nephrotic syndrome, were established in the National Institute of Infectious Diseases (NIID, Tokyo, Japan) and considered a good model of human idiopathic nephrotic syndrome. Recently, we found that the tensin2 gene of the ICGN mouse possessed an 8-nucleotide deletion mutation in exon 18, leading to a frameshift and giving rise to a terminal codon at a premature position (Ref.1).

The ICGN mice develop proteinuria, hypoproteinemia and hyperlipidemia, enemia and severe systemic edema. Conventional histological analyses demonstrated thickened glomerular basement membranes, loss of podocyte foot processes, enlargement of the mesangial area accompanied by cellular proliferation, enlargement of tubules, and tubulointerstitial lesions. This strain would make a contribution to clarify the mechanisms of idiopathic nephrotic syndrome and develop new therapies for nephrotic syndrome (Ref, 2-6).

References
  1. Cho A-R, Uchio-Yamada K, Torigai T, Miyamoto T, Miyoshi I, Matsuda J, Kurosawa T, Kon Y, Asano A, Sasaki N, Agui T. Deficiency of the tensin2 gene in the ICGN mouse, an animal model for congenital nephrotic syndrome. Mammalian Genome, 2006 May;17(5):407-416
  2. Ogura, A., Asano, T., Matsuda, J., Noguchi, Y., Yamamoto, Y., Takano, K. and Nakagawa, M. 1989 Development of nephrotic ICGN mice: the origin, reproductive ability, and incidence of glomerulonephritis. Exp. Anim. 38: 349-352.
  3. Ogura, A., Asano, T., Matsuda, J., Takano, K., Nakagawa, M. and Fukui M. 1989. Characteristics of mutant mice (ICGN) with spontaneous renal lesion: a new model for human nephrotic syndrome. Lab. Anim. 23: 169-174.
  4. Ogura, A., Asano, T., Suzuki, O., Yamamoto, Y., Noguchi, Y., Kawaguchi, H. and Yamaguchi, Y. 1994. Hereditary nephrotic syndrome with progression to renal failure in a mouse model (ICGN strain): clinical study. Nephron 68: 239-244.
  5. Ogura, A., Fujimura, H. Asano, T. Koura, M., Naito, I. and Kobayashi, Y. 1995. Early ultrastructural glomerular alteration in neonatal nephrotic mice (ICGN strain). Vet. Pathol. 32: 321-323.
  6. Uchio, K., Manabe, N. Tamura, K., Miyamoto, M., Ogura, A.,Yamamoto, Y. and Miyamoto, H. 2000. Decreased matrix metalloproteinase activity in the kidneys of hereditary nephrotic mice (ICGN mice). Nephron 86: 145-151.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types spontaneous mutation
Gene symbol Tenc1 (Tensin 2)
Gene name Tensin like C1 domain containing phosphatase
Genotyping information