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Strain Detail

Strain information
Resource No. nbio199
Strain name kisimo
Strain Nomenclature C3H/HeNJcl-Tg(PDE5A)
Common name/Synonyms kisimo spermatogenetic failure mouse
Strain types mutant
Background strain
Institution Mitsubishi Tanabe Pharma Corporation
Developer
Depositor Kazuyuki Kitamura
Conditions of distribution without conditions : contact us
Animal Health Report
Strain description

Homozygous male mice of this strain shows decreasing testis weight, the absence of spermatozoa in epididymis, reduction and abnormality of elongated spermatid, and infertility (spermatogenetic failure). Homozygous female mice of this strain have no abnormality in ovary. This strain has insertion mutation of transgene (human phosphodiesterase 5A) and destroys Testicular haploid expressed gene (Theg) in the kisimo locus.

References
  1. Yanaka N, Kobayashi K, Wakimoto K, Yamada E, Imahie H, Imai Y, Mori C. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. J Biol Chem. 2000 May 19;275(20):14791-4.
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Theg
Gene name testicular haploid expressed gene
Genotyping information