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Strain Detail: kisimo mice
| Strain information |
| Resource No. |
nbio199 |
| Strain name |
kisimo |
| Strain Nomenclature |
C3H/HeNJcl-Tg(PDE5A) |
| Common name/Synonyms |
kisimo spermatogenetic failure mouse |
| Strain types |
mutant |
| Background strain |
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| Institution |
Mitsubishi Tanabe Pharma Corporation |
| Developer |
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| Depositor |
Kazuyuki Kitamura |
| Conditions of distribution |
without conditions: contact us |
| Animal Health Report |
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| Strain description |
Homozygous male mice of this strain shows decreasing testis weight, the absence of spermatozoa in epididymis, reduction and abnormality of elongated spermatid, and infertility (spermatogenetic failure). Homozygous female mice of this strain have no abnormality in ovary. This strain has insertion mutation of transgene (human phosphodiesterase 5A) and destroys Testicular haploid expressed gene (Theg) in the kisimo locus. |
| Reference(s) |
- Yanaka N, Kobayashi K, Wakimoto K, Yamada E, Imahie H, Imai Y, and Mori C. (2000) Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. J Biol Chem 275(20):14791-4. [PMID:10747865]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Theg |
| Gene name |
testicular haploid expressed gene |
| Genotyping information |
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