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Strain Detail

Strain information
Resource No. nbio025
Strain name Lck-Cre
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Faculty of Medicine, Osaka University
Developer Junji Takeda
Depositor Junji Takeda
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

Lck-Cre mice are transgenic mice expressing specifically Cre recombinase in T-cell and used for tissue specific gene disruption. Lck proximal promoter is used to regulate T-cell specific expression. This strain is available for the research of immune system related to T-cell. It's very likely that transgene is inserted into chromosome 7 because of linkage with tyrosinase gene.
References
  1. Takahama Y, Ohishi K, Tokoro Y, Sugawara T, Yoshimura Y, Okabe M, Kinoshita T, Takeda J. Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene. Eur J Immunol. 1998 Jul;28(7):2159-66.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
 Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Lck, Cre
Gene name Lymphocyte-specific protein tyrosine kinase, Cre recombinase
Genotyping information Genotyping protocol for LCK-Cre mice (pdf).