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Strain Detail: Liver-UCP2/D mice

Strain information
Resource No. nbio110
Strain name Liver-UCP2/D
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Division of basic nutrition, National Institute of Health and Nutrition
Developer Nobuyo Kasaoka
Depositor Nobuyo Kasaoka
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Liver-UCP2/D mice are transgenic mice specifically overexpressing human UCP2 in the liver. This strain is available for the research of prevention and therapy for human obesity and diabetes. The human serum amyloid promoter is used for transgene expression. This strain has two lines. A line overexpresses about twice human UCP2 compared with normal mouse whereas D line overexpresses about 10 times it. Futhermore, UCP2 is one of the uncoupling protein related to energy consumption/thermogenesis to uncouple oxidative phosphorylation in the mitochondrial inner membrane, and it expresses extensively in organs.
Reference(s)
  1. Tsuboyama-Kasaoka N, Sano K, Shozawa C, Osaka T, and Ezaki O. (2008) Studies of UCP2 transgenic and knockout mice reveal that liver UCP2 is not essential for the antiobesity effects of fish oil. Am. J. Physiol. Endocrinol. Metab. 294(3):E600-6. [PMID:18089762]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Ucp2
Gene name Uncoupling protein 2
Genotyping information