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Strain Detail: microRNA182 KO mice

Strain information
Resource No. nbio265
Strain name microRNA182 KO
Strain Nomenclature
Common name/Synonyms miRNA182 KO
Strain types mutant
Background strain 129/Sv
Institution Department of Genomic Medicine, National Cerebral and Cardiovascular Center Research Institute
Developer Yukiko Naito (Mouse production by ingenious targeting laboratory, Inc.)
Depositor Yukiko Naito (Currently, Kitasato University School of Allied Health Sciences)
Conditions of distribution

Citation of the literature (Ref. 1) and an acknowledgment to depositor should be included in all publications of research results obtained by use of the biological resource. It's necessary to obtain depositor's consent on use of biological resources:contact us
Animal Health Report
Strain description

Mice of this strain lack MicroRNA-182 (miR-182) gene, which is expressed abundantly in the mammalian retina and is therefore thought to perform important roles for the retinal development and the function. The mice are morphologically normal, viable, and fertile. No significant transcriptional or phenotypic changes are observed in miR-182–depleted retinas.
Reference(s)
  1. Jin ZB, Hirokawa G, Gui L, Takahashi R, Osakada F, Hiura Y, Takahashi M, Yasuhara O, and Iwai N. (2009) Targeted deletion of miR-182, an abundant retinal microRNA. Mol Vis 15:523-33. [PMID:19279690]
Resource information
Cryopreserved sperm In-house Genotype KO
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype Hetero
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Mir182
Gene name microRNA 182
Genotyping information Genotyping protocol for microRNA182 KO mice (pdf).