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Strain Detail: Mlc1-KO mice
| Strain information |
| Resource No. |
nbio413 |
| Strain name |
Mlc1-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Knockout mice of the Mlc1 gene, one of the causative genes of progressive leukoencephalopathy, were generated by deleting exons 2 and 3 by setting guide RNAs in intron 1 and intron 3 of the Mlc1 gene and acting on them simultaneously. It is useful for the study of progressive leukoencephalopathy. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
Heterozyous x B6NCr Slc |
| Genotype |
Heterozygous or wild |
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Mlc1 |
| Gene name |
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) |
| Genotyping information |
|
