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Strain Detail: Mlc1-KO mice

Strain information
Resource No. nbio413
Strain name Mlc1-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Knockout mice of the Mlc1 gene, one of the causative genes of progressive leukoencephalopathy, were generated by deleting exons 2 and 3 by setting guide RNAs in intron 1 and intron 3 of the Mlc1 gene and acting on them simultaneously. It is useful for the study of progressive leukoencephalopathy.

Resource information
Cryopreserved sperm In-house Genotype Heterozygous
Medium Fertiup
From other institutions Genotype
Cryopreserved embryo In-house Mating System Heterozyous x B6NCr Slc
Genotype Heterozygous or wild
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Mlc1
Gene name megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
Genotyping information