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Strain Detail: Mup-KO mice
| Strain information |
| Resource No. |
nbio354 |
| Strain name |
Mup-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
 In mice, even a healthy individual shows proteinuria because major urinary proteins (MUPs) produced in the liver are excreted in the urine in a large quantity. This mouse strain is a strain in which the entire Mup gene cluster has been deleted by genome editing (CRISPR / Cas9). As a result, urinary MUPs (~20 kDa) have completely disappeared (see photo). The strain would be useful as a model for urinary protein research in addition to MUP research. |
| Reference(s) |
- Suzuki O, Koura M, Uchio-Yamada K, and Sasaki M. (2021) Urinary protein analysis in mice lacking major urinary proteins. Exp Anim 70(3):406-411. [PMID:33883349]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
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| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
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| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
Knockout |
| Gene symbol |
Mup (cluster of multiple genes) |
| Gene name |
Major urinary proteins |
| Genotyping information |
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