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Strain Detail: Mup-KO mice

Strain information
Resource No. nbio354
Strain name Mup-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description SDS-PAGE

In mice, even a healthy individual shows proteinuria because major urinary proteins (MUPs) produced in the liver are excreted in the urine in a large quantity. This mouse strain is a strain in which the entire Mup gene cluster has been deleted by genome editing (CRISPR / Cas9). As a result, urinary MUPs (~20 kDa) have completely disappeared (see photo). The strain would be useful as a model for urinary protein research in addition to MUP research.

Reference(s)
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types Knockout
Gene symbol Mup (cluster of multiple genes)
Gene name Major urinary proteins
Genotyping information