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Strain Detail: NDRG1 KO mice

Strain information
Resource No.	nbio062
Strain name	NDRG1 KO
Strain Nomenclature	C57BL/6CrSlc-TgH(Ndrg1)114 NCVC
Common name/Synonyms
Strain types	mutant
Background strain
Institution	National Cerebral and Cardiovascular Center Research Institute
Developer	Toshiyuki Miyata
Depositor	Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution	It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description	NDRG1 KO mice are knockout mice of NDRG1, an ER stress response gene, and model mice of Charcot-Marie-Tooth disease type 4D which is a hereditary neurodegenerative disease in peripheral nerves. This strain is observed movement disorder in hind limbs after about 3 months old, and neurodegeneration with demyelination in the histopathological analysis of sciatic nerves. It's considered that NDRG1 KO mice decrease motor function to demyelinate by decreasing function of Schwann cell because NDRG1 protein highly express in Schwann cells. Incidentally, this strain is possible to breed but low reproductive efficiency, and low birth rate of homo mice.
Reference(s)	Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, and Miyata T. (2004) Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol. Cell. Biol. 24(9):3949-56. [PMID:15082788]

Gene information
Mutation types	knockout
Gene symbol	Ndrg1
Gene name	N-myc downstream regulated 1
Genotyping information	Genotyping PCR for NDRG1 KO mice in PDF format

Animal Resource Bank