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Strain Detail

Strain information
Resource No. nbio062
Strain name NDRG1 KO
Strain Nomenclature C57BL/6CrSlc-TgH(Ndrg1)114 NCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

NDRG1 KO mice are knockout mice of NDRG1, an ER stress response gene, and model mice of Charcot-Marie-Tooth disease type 4D which is a hereditary neurodegenerative disease in peripheral nerves.

This strain is observed movement disorder in hind limbs after about 3 months old, and neurodegeneration with demyelination in the histopathological analysis of sciatic nerves. It's considered that NDRG1 KO mice decrease motor function to demyelinate by decreasing function of Schwann cell because NDRG1 protein highly express in Schwann cells. Incidentally, this strain is possible to breed but low reproductive efficiency, and low birth rate of homo mice.

References
  1. Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, Miyata T. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol. 2004 May;24(9):3949-56.(PMID: 15082788)
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Ndrg1
Gene name N-myc downstream regulated 1
Genotyping information Genotyping PCR for NDRG1 KO mice in PDF format