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Strain Detail

Strain information
Resource No. nbio063
Strain name NDRG1flox
Strain Nomenclature C57BL/6CrSlc-TgH(Ndrg1)Flox114 NCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

NDRG1flox mice are introduced three loxP sites flanking exon 1 of NDRG1 gene and neomycin resistant gene cassette. This strain is possible to delete NDRG1 gene by crossing with Cre expressing mice. It's possible to inactivate NDRG1 stage- or tissue-specifically by selecting different promoter inducing to express Cre recombinase. Please refer to section of NDRG1 KO mice (nbio062).

References
  1. Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, Miyata T. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol. 2004 May;24(9):3949-56.(PMID: 15082788)
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types conditional KO
Gene symbol Ndrg1
Gene name N-myc downstream regulated 1
Genotyping information Genotyping PCR for Ndrg1 flox mice in PDF format.