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Strain Detail: NDRG1flox mice

Strain information
Resource No. nbio063
Strain name NDRG1flox
Strain Nomenclature C57BL/6CrSlc-TgH(Ndrg1)Flox114 NCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

NDRG1flox mice are introduced three loxP sites flanking exon 1 of NDRG1 gene and neomycin resistant gene cassette. This strain is possible to delete NDRG1 gene by crossing with Cre expressing mice. It's possible to inactivate NDRG1 stage- or tissue-specifically by selecting different promoter inducing to express Cre recombinase. Please refer to section ofNDRG1 KOmice (nbio062).

  1. Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, and Miyata T. (2004) Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol. Cell. Biol. 24(9):3949-56. [PMID:15082788]
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types conditional KO
Gene symbol Ndrg1
Gene name N-myc downstream regulated 1
Genotyping information Genotyping PCR for Ndrg1 flox mice in PDF format.