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Strain Detail: Neuregulin-1 (TypeIII) KO

Strain information
Resource No. nbio260
Strain name Neuregulin-1 (TypeIII) KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Department of Pharmacology and Laboratory Animal Resource Facility, National Research Institute for Child Health and Development
Developer Junji Yamauchi, Tomohiro Torii (Mouse production by ingenious targeting laboratory, Inc.)
Depositor Junji Yamauchi, Tomohiro Torii
Conditions of distribution

In publishing the research results obtained by use of the animal resource, a citation of the following literature (ref.1) and the stipulation of an acknowledgment to depositor designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor : contact us

Animal Health Report
Strain description

The neuregulin-1 (TypeIII) KO mice are knockout mice deficient for type III of Neureglin-1 gene. Heterozygous KO (+/−) mice are apparently normal and fertile. The strain is useful for studying the peripheral nerve development and organogenesis of hearts.

References
  1. Wolpowitz D, Mason TB, Dietrich P, Mendelesohn M, Talmage DA, Role LW. Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron (2000) 25:79-91.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype mix of Tg/+ and wild-type
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Nrg1
Gene name Neuregulin 1
Genotyping information