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Strain Detail: NOD.CD72^b mice

Strain information
Resource No.	nbio131
Strain name	NOD.CD72^b
Strain Nomenclature
Common name/Synonyms
Strain types	congenic
Background strain
Institution	Tokyo Medical and Dental University
Developer	Takeshi Tsubata
Depositor	Takeshi Tsubata
Conditions of distribution	It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor. contact us
Animal Health Report
Strain description	NOD mice, a type 1 diabetes spontaneous model mice, have CD72^chaplotype. NOD.CD72^bcongenic mice, which are NOD mice carrying CD72^b, are established by backcrossing between NOD mouse and C57BL/6 mouse carrying CD72^b. NOD.CD72^bmice are remarkably enhanced insulitis or diabetes compared with NOD mouse. NOD mice are widely used for type 1 diabetes spontaneous model, however, the onset of diabetes in NOD mice is affected such as environment and frequency or grade of occurrence is never high. Therefore, NOD mice are often enhanced the symptom by drugs. On the other hand, NOD.CD72^bmice are enhanced diabetes symptom without drug treatment, thus NOD.CD72^bmice are good model of type 1 diabetes and it's useful for the research of diabetes and development of therapeutic drug.
Reference(s)	Hou R, Ohtsuji M, Ohtsuji N, Zhang L, Adachi T, Hirose S, Tsubata T. Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72^bcongenic mice.Biochem Biophys Res Commun. 2009 Feb 27;380(1):193-7.Epub 2009 Jan 22. [PMID: 19167349]

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