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Strain Detail

Strain information
Resource No. nbio131
Strain name NOD.CD72b
Strain Nomenclature
Common name/Synonyms
Strain types congenic
Background strain
Institution Tokyo Medical and Dental University
Developer Takeshi Tsubata
Depositor Takeshi Tsubata
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources.
Only for collaboration with the depositor : contact us
Animal Health Report
Strain description

NOD mice, a type 1 diabetes spontaneous model mice, have CD72c haplotype. NOD.CD72b congenic mice, which are NOD mice carrying CD72b, are established by backcrossing between NOD mouse and C57BL/6 mouse carrying CD72b. NOD.CD72b mice are remarkably enhanced insulitis or diabetes compared with NOD mouse. NOD mice are widely used for type 1 diabetes spontaneous model, however, the onset of diabetes in NOD mice is affected such as environment and frequency or grade of occurrence is never high. Therefore, NOD mice are often enhanced the symptom by drugs. On the other hand, NOD.CD72b mice are enhanced diabetes symptom without drug treatment, thus NOD.CD72b mice are good model of type 1 diabetes and it's useful for the research of diabetes and development of therapeutic drug.

References
  1. Hou R, Ohtsuji M, Ohtsuji N, Zhang L, Adachi T, Hirose S, Tsubata T. Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice. Biochem Biophys Res Commun. 2009 Feb 27;380(1):193-7. Epub 2009 Jan 22. [PMID: 19167349]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types spontaneus mutation
Gene symbol Cd72
Gene name Cd72 molecule
Genotyping information