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Strain Detail

Strain information
Resource No. nbio187
Strain name OH-1
Strain Nomenclature
Common name/Synonyms
Strain types hybrid
Background strain
Institution Department of Community Health and Epidemiology, Faculty of Medicine, Nara Medical University
Developer
Depositor Osamu Hatano
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

This strain shows gait disturbance and growth retardation. These mice spontaneously appeared in the colony of inbred C57BL/6N Jcl mice. These mice show significant postnatal growth retardation and almost all babies die in infancy. Even if babies survive after weaning, they become gait disturbance. The result of breeding test showed that phenotypes of this strain were autosomal dominant inheritance and heterozygous mice also showed such symptoms. As a result of soft X-ray analysis, these mice observed tibial dysgenesis, compensatory hypertrophy of fibula and mirror-image polydactyly in all four limbs. This strain is similar to phenotypes of hemimelic extratoes (Hx) reported in mice, but these mice don't observe any mutation such as base substitution in close to Hx mutation sites. As a result of microsatellite analysis after mating with DBA/2, it found that this strain had mutation in the chromosome 5. At present, this strain is maintained as hybrid strain between C57BL/6N Jcl and DBA/2Cr Slc.

References
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse Approx. 2 months
Gene information
Mutation types spontaneus mutation
Gene symbol unknown
Gene name unknown
Genotyping information