HOME > mice > C57BL/6-Tg(p35/EGFP)Kyo mice

Strain Detail

Strain information
Resource No. nbio226
Strain name C57BL/6-Tg(p35/EGFP)Kyo
Strain Nomenclature C57BL/6-Tg(p35/EGFP)Kyo
Common name/Synonyms βMHC-p35 Tg, p35/EGFP
Strain types mutant
Background strain
Institution Department of Animal Development and Physiology, Kyoto University
Developer
Depositor Kazuhiro Sakamaki
Conditions of distribution In publishing the research results obtained by use of the animal resource, a citation of the following literature (ref.1) and the stipulation of an acknowledgment to depositor designated by the depositor is requested. : contact us
Animal Health Report
Strain description

βMHC-p35 Tg mice are transgenic mice specifically expressing baculovirus p35 and EGFP by mouse βMHC promoter in cardiomyocytes. Baculovirus p35, a caspase inhibitor, is known to stop apoptosis in host cells, thus this strain is useful for the research of apoptosis in cardiomyocytes.

References
  1. Yajima N, Yamada S, Morisaki T, Toyokuni S, Yonehara S, Sakamaki K. Partial correction of abnormal cardiac development in caspase-8-deficient mice by cardiomyocyte expression of p 35. Transgenic Res. 2005 Oct;14(5):593-604.
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Myh7, p35, EGFP
Gene name [myosin, heavy chain 7, cardiac muscle, beta], p35, Enhanced Green Fluorescent Protein
Genotyping information