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Strain Detail: TS3; Agouti-revertant; pink mice

Strain information
Resource No. nbio244
Strain name TS3; Agouti-revertant; pink
Strain Nomenclature HSP5-ru2
Common name/Synonyms pink
Strain types mutant
Background strain C57BL/6
Institution Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu Univesrsity
Developer Hiroshi Tekemori
Depositor Hiroshi Tekemori
Conditions of distribution Please contact us for terms and conditions.
Animal Health Report
Strain description

This strain is a C57BL/6-derived spontaneous mutant mouse model, in which chronic diarrhea continues even if Sodium Dextran Sulfate (DSS) is stopped after diarrhea induction by DSS, indicating that the strain can be used as a mouse model of Crohn's disease, one of the incurable diseases.

Mice of the strain are called "light-color red-eye mice" or pink mice because they have color reductions in coats and eyes (i.e., light-brown coats and pink eyes, respectively). These color reductions are due to a point mutation in the Hps5 gene involved in Hermansky-Padlak syndrome (an incurable disease specified by the Japanese government, #164).

Because of high demand from pharmaceutical companies, the laboratory animal resource bank at NIBIOHN entered into a license sales agreement with Japan SLC Co., Ltd. which will produce and sell mice of this strain. Currently, in collaboration with SLC, we are constructing an efficient breeding method for mass production (homozygous individuals have low fertility) and SNP Genotyping method. We are also collecting basic data such as feed effects on diarrhea induction and drug reactivity in the strain.

Reference(s)
  1. Itoh Y, Nagaoka Y, Katakura Y, Kawahara H, and Takemori H. (2016) Simple chronic colitis model using hypopigmented mice with a Hermansky-Pudlak syndrome 5 gene mutation. Pigment Cell Melanoma Res 29(5):578-82. [PMID:27333462]
Resource information
Cryopreserved sperm In-house Genotype Homozygous
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System IVF
Genotype Heterozygous
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types Spontaneous mutation
Gene symbol Hps5
Gene name Hermansky-Pudlak syndrome 5
Genotyping information
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