HOME > mice > TS3; Agouti-revertant; pink mice
Strain Detail: TS3; Agouti-revertant; pink mice
|Strain name||TS3; Agouti-revertant; pink|
|Institution||Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu Univesrsity|
|Conditions of distribution||Please contact us for terms and conditions.|
|Animal Health Report|
This strain is a C57BL/6-derived spontaneous mutant mouse model, in which chronic diarrhea continues even if Sodium Dextran Sulfate (DSS) is stopped after diarrhea induction by DSS, indicating that the strain can be used as a mouse model of Crohn's disease, one of the incurable diseases.
Mice of the strain are called "light-color red-eye mice" or pink mice because they have color reductions in coats and eyes (i.e., light-brown coats and pink eyes, respectively). These color reductions are due to a point mutation in the Hps5 gene involved in Hermansky-Padlak syndrome (an incurable disease specified by the Japanese government, #164).
Because of high demand from pharmaceutical companies, the laboratory animal resource bank at NIBIOHN entered into a license sales agreement with Japan SLC Co., Ltd. which will produce and sell mice of this strain. Currently, in collaboration with SLC, we are constructing an efficient breeding method for mass production (homozygous individuals have low fertility) and SNP Genotyping method. We are also collecting basic data such as feed effects on diarrhea induction and drug reactivity in the strain.
|From other institutions||Genotype|
|Cryopreserved embryo||In-house||Mating System||IVF|
|From other institutions||Mating System|
|Strain status / Availability||Cryopreserved sperm||Within 1 month|
|Cryopreserved embryo||Within 1 month|
|Live animals||Approx. 2 months|
|Mutation types||Spontaneous mutation|
|Gene name||Hermansky-Pudlak syndrome 5|