Strain Detail: RP58 KO mice

RP58 KO mice are knockout mice deleted for all exsons of mouse RP58 gene (full-length ; 4 kb).

These mice are postpartum lethality and observed abnormal layer formation of cerebral cortex neuron. That is, these mice are observed outside-in the layer formation of cortex with deletion of sub plate layer whereas normal mice have six aligned cell layer regularly from cortical layer in the cerebral cortex. These mice are also observed serious symptoms in the process of differentiation of cerebral cortex neuron or pathway formation between cerebral cortex and thalamus. It's considered that this strain is important model mice to comprehend molecular mechanism of brain formation.

1. Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, and Kasai M. (2009) The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev. Biol. 331(2):140-51. [PMID:19409883]