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Strain Detail: FVB/N-Tg(PrPATTCT160)Bay mice

Strain information
Resource No. nbio201
Strain name FVB/N-Tg(PrPATTCT160)Bay
Strain Nomenclature FVB/N-Tg(PrPATTCT160)Bay
Common name/Synonyms SCA10
Strain types mutant
Background strain
Institution Baylor College of Medicine
Depositor Tohru Matsuura (Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)
Conditions of distribution In publishing the research results obtained by use of the animal resource, the stipulation of an acknowledgment to depositor designated by the depositor is requested. :contact us
Animal Health Report
Strain description

This strain is a model mouse for the analysis of spinocerebellar ataxia type 10 (SCA10), which is an incurable disease. SCA10 is a dominantly-inherited neurodegenerative disease whose cardinal signs are cerebellar ataxia and epilepsy, and clinical symptoms are rich in diversity. SCA10 is caused by unstable abnormal elongation of ATTCT repeats in intron 9 of ATXN10 gene and it's only hexanucleotide repeat disease for human. This strain is a transgenic mouse expressing 160 ATTCT repeats under the control of murine prion promoter (ref.1).

  1. Borchelt DR, Davis J, Fischer M, Lee MK, Slunt HH, Ratovitsky T, Regard J, Copeland NG, Jenkins NA, Sisodia SS, and Price DL. (1996) A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13(6):159-63. [PMID:9117892]
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Atxn10, Prnp
Gene name ataxin 10, prion protein
Genotyping information