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Strain Detail

Strain information
Resource No. nbio133
Strain name SCG/ThpNkc
Strain Nomenclature
Common name/Synonyms SCG/Kj mice
Strain types inbred
Background strain
Institution Tohoku University
Developer Koken Kinjoh (Tohoku University)
Depositor Masanobu Suzuki (NIPPON KAYAKU Co., Ltd.)
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. The recipient must contact the depositor in the case of application for any publications, patents or commercial use with the results from the use of the biological resource. : contact us
Animal Health Report
Strain description Photo of SCG/Kj mice

SCG/ThpNkc mice are a model of rapidly progressive glomerulonephritis, which is an intractable disease. This strain is an inbred strain established by sib mating between hybrid strains, BXSB/MpJ (BXSB) female and MRL/MpJ-lpr/lpr (MRL/lpr) male. This strain becomes crescentic glomerulonephritis and ANCA-associated vasculitis not observed in BXSB and MRL/lpr, and dies at early age compared with BXSB and MRL/lpr. It's considered because this strain has autoimmune accelerating gene lpr (Faslpr) and BXSB/MpJ background.

Method of strain maintenance

Mating starts at 6 weeks old because female of this strain often becomes glomerulonephritis and vasculitis at about 8 weeks old. The strain maintenance carries out following. To maintain incidence rate, mother is checked urine protein and urine occult blood using uro-paper (Eiken) after weaning, then positive mouse in the urinalysis is identified crescent formation and onset of vasculitis by the renal histopathological observation.

References
  1. Kinjoh K, Kyogoku M, Good RA. Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3413-7. [PMID: 8475090]
  2. Neumann I, Birck R, Newman M, SchnüEle P, Kriz W, Nemoto K, Yard B, Waldherr R, Van Der Woude FJ. SCG/Kinjoh mice: a model of ANCA-associated crescentic glomerulonephritis with immune deposits. Kidney Int. 2003 Jul;64(1):140-8. [PMID: 12787404]
  3. Ishida-Okawara A, Ito-Ihara T, Muso E, Ono T, Saiga K, Nemoto K, Suzuki K. Neutrophil contribution to the crescentic glomerulonephritis in SCG/Kj mice. Nephrol Dial Transplant. 2004 Jul;19(7):1708-15. [PMID: 15150352]
  4. Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K. Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. J Immunol. 2006 Mar 15;176(6):3662-73. [PMID: 16517735]
  5. Saiga K, Tokunaka K, Ichimura E, Toyoda E, Abe F, Yoshida M, Furukawa H, Nose M, Ono M. NK026680, a novel suppressant of dendritic cell function, prevents the development of rapidly progressive glomerulonephritis and perinuclear antineutrophil cytoplasmic antibody in SCG/Kj mice. Arthritis Rheum. 2006 Nov;54(11):3707-15. [PMID: 17075885]
  6. Saiga K, Yoshida M, Nakamura I, Toyoda E, Tokunaka K, Morohashi H, Abe F, Nemoto K, Nose M. Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice. Int Immunopharmacol. 2008 Sep;8(9):1183-9. [PMID: 18602063]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types spontaneus mutation
Gene symbol Faslpr
Gene name Fas (TNF receptor superfamily member 6)
Genotyping information