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Strain Detail: SCG/ThpNkc mice
Strain information | |
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Resource No. | nbio133 |
Strain name | SCG/ThpNkc |
Strain Nomenclature | |
Common name/Synonyms | SCG/Kj mice |
Strain types | inbred |
Background strain | |
Institution | Tohoku University |
Developer | Koken Kinjoh (Tohoku University) |
Depositor | Akira Masuda (NIPPON KAYAKU Co., Ltd.) |
Conditions of distribution | In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. The recipient must contact the depositor in the case of application for any publications, patents or commercial use with the results from the use of the biological resource. :contact us |
Animal Health Report | |
Strain description | ![]() SCG/ThpNkc mice are a model of rapidly progressive glomerulonephritis, which is an intractable disease. This strain is an inbred strain established by sib mating between hybrid strains, BXSB/MpJ (BXSB) female and MRL/MpJ-lpr/lpr(MRL/lpr) male. This strain becomes crescentic glomerulonephritis and ANCA-associated vasculitis not observed in BXSB and MRL/lpr, and dies at early age compared with BXSB and MRL/lpr. It's considered because this strain has autoimmune accelerating gene lpr (Faslpr) and BXSB/MpJ background. Method of strain maintenanceMating starts at 6 weeks old because female of this strain often becomes glomerulonephritis and vasculitis at about 8 weeks old. The strain maintenance carries out following. To maintain incidence rate, mother is checked urine protein and urine occult blood using uro-paper (Eiken) after weaning, then positive mouse in the urinalysis is identified crescent formation and onset of vasculitis by the renal histopathological observation. |
Reference(s) |
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Resource information | |||
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Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Method | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live animals | Approx. 2 months |
Gene information | |
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Mutation types | spontaneus mutation |
Gene symbol | Faslpr |
Gene name | Fas (TNF receptor superfamily member 6) |
Genotyping information |