Strain Detail: SCG/ThpNkc mice

SCG/ThpNkc mice are a model of rapidly progressive glomerulonephritis, which is an intractable disease. This strain is an inbred strain established by sib mating between hybrid strains, BXSB/MpJ (BXSB) female and MRL/MpJ-lpr/lpr(MRL/lpr) male. This strain becomes crescentic glomerulonephritis and ANCA-associated vasculitis not observed in BXSB and MRL/lpr, and dies at early age compared with BXSB and MRL/lpr. It's considered because this strain has autoimmune accelerating gene lpr (Fas^lpr) and BXSB/MpJ background.

Method of strain maintenance

Mating starts at 6 weeks old because female of this strain often becomes glomerulonephritis and vasculitis at about 8 weeks old. The strain maintenance carries out following. To maintain incidence rate, mother is checked urine protein and urine occult blood using uro-paper (Eiken) after weaning, then positive mouse in the urinalysis is identified crescent formation and onset of vasculitis by the renal histopathological observation.

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