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Strain Detail: Sftpa1-KO mice

Strain information
Resource No. nbio369
Strain name Sftpa1-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

The mice are knockout mice of surfactant-associated protein a1 (SFTPA1), a lung surfactant protein. It was created by deleting the entire coding region of the Sftpa1 gene by setting guide RNAs in the 5'-UTR and 3'-UTR by genome editing. SFTPA1 functions as a surfactant that relaxes surface tension in the alveoli and is responsible for innate immunity in the alveoli. Mutations in SFTPA1 cause pulmonary fibrosis (e.g., Takezaki et al., 2019), and this mouse strain would be useful as a model for idiopathic pulmonary fibrosis.
Reference(s)
  1. Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, and Yasutomo K. (2019) A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis. J Exp Med 216(12):2724-2735. [PMID:31601679]
Resource information
Cryopreserved sperm In-house Genotype
Medium
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals
Gene information
Mutation types knockout
Gene symbol Sftpa1
Gene name surfactant associated protein A1
Genotyping information