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Strain Detail: ShDock7 Tg mice

Strain information
Resource No. nbio246
Strain name ShDock7 Tg
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Pharmacology and Laboratory Animal Resource Facility, National Research Institute for Child Health and Development
Developer Junji Yamauchi, Tomohiro Torii
Depositor Junji Yamauchi, Tomohiro Torii
Conditions of distribution In publishing the research results obtained by use of the animal resource, a citation of the following literature (ref.1, 2) and the stipulation of an acknowledgment to depositor designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. Only for collaboration with the depositor. contact us
Animal Health Report
Strain description

This strain is a systemic knockdown mouse expressing Dock7 short hairpin (sh) RNA. Dock7, a member of Rho family which are low-molecular-weight GTP-binding proteins, is an activating factor and expressing in whole body, so this strain is able to use to analyze it in various tissues. The research of this strain showed that Dock7 specifically inhibited myelin membrane sheath formation in peripheral nerves. This strain is expected to apply for the therapy of peripheral neurodegenerative disease, the type of myelin diseases.
Reference(s)
  1. Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, and Tanoue A. (2011) The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination. J Neurosci 31(35):12579-92. [PMID:21880919]
  2. Torii T, Miyamoto Y, Nagao M, Onami N, Tsumura H, Maeda M, Nakamura K, Tanoue A, Yamauchi J. (2012) Knockdown of Dock7 in vivo specifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness. Am J Mol Biol 2:210-216.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Dock7
Gene name dedicator of cytokinesis 7
Genotyping information