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Strain Detail: SIK2-KO mice
| Strain information |
| Resource No. |
nbio071 |
| Strain name |
SIK2-KO |
| Strain Nomenclature |
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| Common name/Synonyms |
C57BL/6 SIK2-KO mice |
| Strain types |
mutant |
| Background strain |
|
| Institution |
ProteinExpress Co., Ltd. |
| Developer |
Shunsuke Watanabe |
| Depositor |
Shunsuke Watanabe |
| Conditions of distribution |
It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
SIK2-KO mice are knockout mice of SIK2, a protein kinase which belong to AMP dependent protein kinase (AMPK) family. Salt Inducible Kinase (SIK) is isolated from adrenal gland of rat fed high salt containing food as a factor about control of aldosterone synthesis. It has three isoforms, SIK1, SIK2, SIK3. This strain is available for research of carbohydrate or liqid metabolism because SIK2 expresses highly in adipocytes and it's suggested that SIK2 participates with insulin signal transduction. |
| Reference(s) |
- Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, and Okamoto M. (2003) Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J. Biol. Chem. 278(20):18440-7. [PMID:12624099]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
|
| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
|
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Sik2 |
| Gene name |
Salt-inducible kinase 2 |
| Genotyping information |
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