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Strain Detail

Strain information
Resource No. nbio071
Strain name SIK2-KO
Strain Nomenclature
Common name/Synonyms C57BL/6 SIK2-KO mice
Strain types mutant
Background strain
Institution ProteinExpress Co., Ltd.
Developer Shunsuke Watanabe
Depositor Shunsuke Watanabe
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

SIK2-KO mice are knockout mice of SIK2, a protein kinase which belong to AMP dependent protein kinase (AMPK) family. Salt Inducible Kinase (SIK) is isolated from adrenal gland of rat fed high salt containing food as a factor about control of aldosterone synthesis. It has three isoforms, SIK1, SIK2, SIK3. This strain is available for research of carbohydrate or liqid metabolism because SIK2 expresses highly in adipocytes and it's suggested that SIK2 participates with insulin signal transduction.

References
  1. Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J Biol Chem. 2003 May 16;278(20):18440-7. (PMID: 12624099)
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Sik2
Gene name Salt-inducible kinase 2
Genotyping information