HOME > mice > skDNTRPV2-TG mice

Strain Detail

Strain information
Resource No. nbio250
Strain name skDNTRPV2-TG
Strain Nomenclature
Common name/Synonyms transgenic mice with skeletal-muscle-specific overexpression of dominant-negative TRPV2
Strain types mutant
Background strain C57BL/6J
Institution National Cerebral and Cardiovascular Center Research Institute, Department of Molecular Physiology
Developer Yuko Iwata
Depositor Yuko Iwata
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

The skDNTRPV2-TG mice are transgenic mice with skeletal-muscle-specific expression of channel-pore mutant proteins (E604K) of transient receptor potential cation channel, subfamily V, member 2 (TRPV2). The mice are useful for studying a role of TRPV2 in skeletal muscles.

References
  1. Iwata Y, Katanosaka Y, Arai Y, Shigekawa M, Wakabayashi S. Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models. Hum Mol Genet. 2009 Mar 1;18(5):824-34.
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Trpv2, ACTA1
Gene name mouse transient receptor potential cation channel, subfamily V, member 2; human α-skeletal actin promoter
Genotyping information